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Other important signaling mechanisms involve Rho and MAP kinases which modulate the expression of proteolytic enzymes, proinflammatory cytokines, autophagy and contractility (29, 30)
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6.1 Targeting core metabolic pathways represents a primary approach In glucose metabolism, exploiting the Warburg effect—driven by GLUT1 and glycolytic enzymes like HK2 and PKM2—is pivotal
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