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Medications and Supplements Metformin: May increase MMA by reducing B12 absorption Proton pump inhibitors: Can raise MMA by decreasing stomach acid needed for B12 absorption Birth control pills: May increase MMA by affecting B12 metabolism Anticonvulsants: Can raise MMA by interfering with B12 H2 blockers: May increase MMA by reducing stomach acid production Testing Accuracy and Stability Factors That Can Affect the Accuracy of Your Test Dehydration can artificially increase MMA levels by concentrating it in the blood A recent meal with animal products can temporarily increase levels Recent exercise can temporarily elevate levels Pregnancy naturally lowers levels How it Relates to Other Markers Your healthcare provider may compare your MMA results to other tests to get a more complete picture of your B12 status
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